Allosteric PI3Kα Inhibition Overcomes On-target Resistance to Orthosteric Inhibitors Mediated by Secondary PIK3CA Mutations
- Andreas Varkaris
- Ferran Fece de la Cruz
- et al.
- 2023
- Cancer Discovery
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6 results at Cancer Discovery
AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer
- Ashish Noronha
- Nishanth Belugali Nataraj
- et al.
- 2022
- Cancer Discovery
Parallel genomic alterations of antigen and payload targets mediate polyclonal acquired clinical resistance to sacituzumab govitecan in triple-negative breast cancer
- James T. Coates
- Sheng Sun
- et al.
- 2021
- Cancer Discovery
Longitudinal single-cell dynamics of chromatin accessibility and mitochondrial mutations in chronic lymphocytic leukemia mirror disease history
- Livius Penter
- Satyen H. Gohil
- et al.
- 2021
- Cancer Discovery
The lipogenic regulator srebp2 induces transferrin in circulating melanoma cells and suppresses ferroptosis
- Xin Hong
- Whijae Roh
- et al.
- 2020
- Cancer Discovery
Mechanism-based epigenetic chemosensitization therapy of diffuse large B-cell lymphoma
- Thomas Clozel
- Shao Ning Yang
- et al.
- 2013
- Cancer Discovery