Organic catalysis: enabling functional and biodegradable polycarbonates for drug-resistance solutions
- 2025
- ACS Spring 2025
James L. Hedrick is a Distinguished Research Staff Member at IBM’s Almaden Research Center, where he currently focuses his efforts in AI-assisted catalyst discovery for polymer synthesis. He is also a Visiting Scholar at Stanford University and maintains a long-standing affiliation with the Institute of Bioengineering and Nanotechnology (IBN) in Singapore.
Over the course of his career, Jim has pioneered novel polymer-forming reactions, including the development of high-temperature interlayer dielectrics and block copolymers for low dielectric materials—foundational to block copolymer lithography. He introduced the polymer community to organic catalysis as an environmentally benign route to living polymerization, opening new avenues in nanomedicine, degradable polymers, and polymer recycling.
These advances have fueled translational research addressing critical challenges such as antimicrobial resistance, gene delivery, sustained therapeutic release, and cancer therapies. His work has led to multiple spin-off companies focused on polymer recycling and nanoscale lithographic patterning.
Jim is the author of over 570 publications and holds approximately 545 patents. He serves on numerous scientific advisory boards and has received many prestigious honors, including:
Currently, Jim is engaged in a diverse, multidisciplinary effort to accelerate the discovery of sustainable and high-performance materials using artificial intelligence.
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