Gowri Nayar, Ignacio Terrizzano, et al.
Frontiers in Genetics
A series of analogues designed to assess the importance of the amide bond in the dipeptide sweetener L-aspartyl-L-phenylalanine methyl ester has been synthesized and tested. The peptide bond was methylated, replaced by an ester bond, or reversed. All of these modifications produced compounds that did not have a sweet taste. We conclude that the steric, electronic, and directional characteristics of the amide bond are essential for biological activity in the dipeptide sweeteners. © 1980, American Chemical Society. All rights reserved.
Gowri Nayar, Ignacio Terrizzano, et al.
Frontiers in Genetics
Huajun Chen, Guotong Xie
Expert Opinion on Drug Discovery
Joshua Hui, Sarah Knoop, et al.
IHI 2012
John D. Gould
Journal of Experimental Psychology