J. Michael Schmidt, Daby Sow, et al.
Neurocritical Care
A series of analogues designed to assess the importance of the amide bond in the dipeptide sweetener L-aspartyl-L-phenylalanine methyl ester has been synthesized and tested. The peptide bond was methylated, replaced by an ester bond, or reversed. All of these modifications produced compounds that did not have a sweet taste. We conclude that the steric, electronic, and directional characteristics of the amide bond are essential for biological activity in the dipeptide sweeteners. © 1980, American Chemical Society. All rights reserved.
J. Michael Schmidt, Daby Sow, et al.
Neurocritical Care
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ChemBioChem
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International Journal of Health Geographics
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