Programmed Temperature Gas Chromatography

A derivation of solute retention behavior in programmed temperature gas chromatography is presented. The final equation, for the dependence of retention time on heating rate, mass flow rate of carrier gas, and starting temperature, was integrated by computer for a linear temperature program, and yielded results in good agreement with experiment. A correlation is noted between relative retention time and the ratio of flow rate to heating rate. Under identical linear temperature programming conditions, increasing the liquid phase polarity increases the retention time of each member of a polar homologous series by the same amount. The effect of liquid phase loading on resolution and the limitations imposed by the liquid phase are discussed. © 1960, American Chemical Society. All rights reserved.